Prospective applications of bioactive materials in orthopedic therapies: A review

作者：Wenqing Liang, Chao Zhou, Juqin Bai, Hongwei Zhang, Hengguo Long, Bo Jiang, Jiangwei Wang, Xiaogang Huang, Hengjian Zhang, Jiayi Zhao · 发表于：Heliyon · 年份：2024 · DOI：10.1016/j.heliyon.2024.e36152 · 被引用次数：42 · 研究领域：Bone Tissue Engineering Materials、Orthopaedic implants and arthroplasty、Graphene and Nanomaterials Applications

The biomedical application of biodegradable polymers for addressing bone-related diseases has garnered considerable attention in recent years. Advances in material technology have expanded the repertoire of materials suitable for orthopedic implants, with nanomaterials playing a pivotal role in replicating crucial surface properties akin to natural tissues. This comprehensive review explores the evaluation of bioactive glass ceramics, shedding light on their properties and applications. The synthesis of composites through composite manufacturing has emerged as a strategy to enhance biocompatibility and biomechanical characteristics. They are addressing challenges associated with conventional implants and nanomaterials, whether in the form of functional nano coatings or nanostructured surfaces, present opportunities to refine implant techniques. Novel developments in orthopedic biomaterials, such as smart biomaterials, porous structures, and 3D implants, offer stimuli-responsive behavior to achieve desired implant shapes and characteristics. Bioactive and biodegradable porous polymer/inorganic composite materials are explored for bone tissue engineering scaffolds, aiming to promote bone formation and regeneration. As a prospective direction, the integration of stem cells into scaffolds hints at the creation of next-generation synthetic/living hybrid biomaterials, displaying high adaptability in biological settings. This review establishes a foundation for nanotechnology-driven...