Asperuloside as a Novel NRF2 Activator to Ameliorate Endothelial Dysfunction in High Fat Diet-Induced Obese Mice

作者：Chufeng He, Ruiwen Zhu, Lei He, Chui Yiu Bamboo Chook, Huixian Li, Fung Ping Leung, Gary Tse, Zhen‐Yu Chen, Yu Huang, Wing Tak Wong · 发表于：Antioxidants and Redox Signaling · 年份：2024 · DOI：10.1089/ars.2024.0593 · 被引用次数：10 · 研究领域：Eicosanoids and Hypertension Pharmacology、Adipose Tissue and Metabolism、Cardiovascular, Neuropeptides, and Oxidative Stress Research

Aims: Current treatments are inadequate in alleviating obesity-associated vascular diseases. The development of effective therapies to ameliorate endothelial dysfunction and attenuate oxidative stress is of utmost importance. Asperuloside (ASP), a bioactive compound extracted from Eucommia species, exhibits antiobesity properties. However, the effects of ASP on vasculopathy have not been investigated. Therefore, the effects of ASP on vascular dysfunction and related mechanisms were elucidated.