Human adolescent brain similarity development is different for paralimbic versus neocortical zones

作者：Lena Dorfschmidt, František Váša, Simon R. White, Rafael Romero-García, Manfred G. Kitzbichler, Aaron Alexander‐Bloch, Matthew Cieslak, Kahini Mehta, Theodore D. Satterthwaite, Richard A. I. Bethlehem, Jakob Seidlitz, Petra E. Vértes, Edward T. Bullmore, Edward T. Bullmore, Raymond J. Dolan, Ian Goodyer, Peter Fonagy, Peter B. Jones, Michael Moutoussis, Tobias U. Hauser, Sharon Neufeld, Rafael Romero-García, Michelle St Clair, Petra E. Vértes, Kirstie Whitaker, Becky Inkster, Gita Prabhu, Cinly Ooi, Umar Toseeb, Barry Widmer, Junaid Bhatti, Laura Villis, Ayesha Alrumaithi, Sarah Birt, Aislinn Bowler, Kalia Cleridou, Hina Dadabhoy, Emma Davies, Ashlyn Firkins, Sian Granville, Elizabeth Harding, Alexandra Hopkins, Daniel Isaacs, Janchai King, Danae Kokorikou, Christina Maurice, Cleo McIntosh, Jessica Memarzia, Harriet L. Mills, Ciara O’Donnell, Sara Pantaleone, Jenny Scott, Beatrice Kiddle, Ela Polek, Pasco Fearon, John Suckling, Anne‐Laura van Harmelen, Rogier Kievit, Sam Chamberlain, Richard A. I. Bethlehem · 发表于：Proceedings of the National Academy of Sciences · 年份：2024 · DOI：10.1073/pnas.2314074121 · 被引用次数：10 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、EEG and Brain-Computer Interfaces

Adolescent development of human brain structural and functional networks is increasingly recognized as fundamental to emergence of typical and atypical adult cognitive and emotional proodal magnetic resonance imaging (MRI) data collected from N [Formula: see text] 300 healthy adolescents (51%; female; 14 to 26 y) each scanned repeatedly in an accelerated longitudinal design, to provide an analyzable dataset of 469 structural scans and 448 functional MRI scans. We estimated the morphometric similarity between each possible pair of 358 cortical areas on a feature vector comprising six macro- and microstructural MRI metrics, resulting in a morphometric similarity network (MSN) for each scan. Over the course of adolescence, we found that morphometric similarity increased in paralimbic cortical areas, e.g., insula and cingulate cortex, but generally decreased in neocortical areas, and these results were replicated in an independent developmental MRI cohort (N [Formula: see text] 304). Increasing hubness of paralimbic nodes in MSNs was associated with increased strength of coupling between their morphometric similarity and functional connectivity. Decreasing hubness of neocortical nodes in MSNs was associated with reduced strength of structure-function coupling and increasingly diverse functional connections in the corresponding fMRI networks. Neocortical areas became more structurally differentiated and more functionally integrative in a metabolically expensive process linked to c...