The gut-microbiome in adult Attention-deficit/hyperactivity disorder - A Meta-analysis

作者：Babette Jakobi, Priscilla Vlaming, Danique Mulder, Marta Ribasés, Vanesa Richarte, Josep Antoni Ramos‐Quiroga, Indira Tendolkar, Philip van Eijndhoven, Janna N. Vrijsen, Jan K. Buitelaar, Barbara Franke, Martine Hoogman, Mirjam Bloemendaal, Alejandro Arias Vásquez · 发表于：European Neuropsychopharmacology · 年份：2024 · DOI：10.1016/j.euroneuro.2024.07.004 · 被引用次数：9 · 研究领域：Attention Deficit Hyperactivity Disorder、Tryptophan and brain disorders、Gut microbiota and health

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition that persists into adulthood in the majority of individuals. While the gut-microbiome seems to be relevant for ADHD, the few publications on gut-microbial alterations in ADHD are inconsistent, in the investigated phenotypes, sequencing method/region, preprocessing, statistical approaches, and findings. To identify gut-microbiome alterations in adult ADHD, robust across studies and statistical approaches, we harmonized bioinformatic pipelines and analyses of raw 16S rRNA sequencing data from four adult ADHD case-control studies (NADHD=312, NNoADHD=305). We investigated diversity and differential abundance of selected genera (logistic regression and ANOVA-like Differential Expression tool), corrected for age and sex, and meta-analyzed the study results. Converging results were investigated for association with hyperactive/impulsive and inattentive symptoms across all participants. Beta diversity was associated with ADHD diagnosis but showed significant heterogeneity between cohorts, despite harmonized analyses. Several genera were robustly associated with adult ADHD; e.g., Ruminococcus_torques_group (LogOdds=0.17, pfdr=4.42 × 10–2), which was more abundant in adults with ADHD, and Eubacterium_xylanophilum_group (LogOdds= -0.12, pfdr=6.9 × 10–3), which was less abundant in ADHD. Ruminococcus_torques_group was further associated with hyperactivity/impulsivity symptoms and Eisenbergiella with ...