Effect of home-based and remotely supervised combined exercise and cognitive intervention on older adults with mild cognitive impairment (COGITO): study protocol for a randomised controlled trial

作者：Chenlu Hong, TakChing Tai, Jianwei Zhou, Changqing Gao, Jianfei Shi, J. C. Huang, Xuebing Xu, Yushan Du, Guangwen Liu, Boyuan Guan, Xin Ning, Xinran Liu, Zhaorui Liu, Yanan Luo · 发表于：BMJ Open · 年份：2024 · DOI：10.1136/bmjopen-2023-081122 · 被引用次数：10 · 研究领域：Dementia and Cognitive Impairment Research、Intensive Care Unit Cognitive Disorders、Cancer-related cognitive impairment studies

INTRODUCTION: Mild cognitive impairment (MCI) is an intermediate phase between normal cognitive ageing and dementia and poses a serious threat to public health worldwide; however, it might be reversible, representing the best opportunity for secondary prevention against serious cognitive impairment. As a non-pharmacological intervention for those patients, interventions that combine physical exercise and cognitive training, whether delivered simultaneously or sequentially, may have superior effects on various cognitive domains, including global cognition, memory, executive function and attention. The supportive evidence remains incomplete. This study aims to assess the effectiveness of a combined exercise and cognitive intervention in Chinese older adults with mild cognitive impairment (COGITO), empowered by digital therapy and guided by the Health Action Process Model and the Theory of Planned Behaviour (HAPA-TPB theory) in a home-based setting. METHODS AND ANALYSIS: This study is a randomised controlled, assessor-blinded multi-centre study. Four parallel groups will include a total of 160 patients, receiving either a combined exercise and cognitive intervention, an isolated exercise intervention, an isolated cognitive intervention or only health education. These interventions will be conducted at least twice a week for 50 min each session, over 3 months. All interventions will be delivered at home and remotely monitored through RehabApp and Mini-programme, along with an arm...