Light-Induced 1,3-Thiosulfonylation of β,γ-Unsaturated Ketones with Thiosulfonates

作者：Jiuwen Xu, Bo-Xi Liu, Xinyu Liu, Weidong Rao, Shun‐Yi Wang · 发表于：Organic Letters · 年份：2024 · DOI：10.1021/acs.orglett.4c01925 · 被引用次数：23 · 研究领域：Sulfur-Based Synthesis Techniques、Radical Photochemical Reactions、Chemical Synthesis and Reactions

Sulfur-containing compounds exhibit potent significance in drug molecules. Thiosulfonates as 1,3-thiosulfonylation reactants to olefins have yet to be investigated. Herein, we report photoinduced 1,3-difunctionalization of β,γ-unsaturated ketones with thiosulfonates, which undergo a radical 1,2-acyl shift. The protocol features mild conditions, high regioselectivity, and 100% atom economy.