Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging

作者：Ling Qiu, Chuang Liang, Peter Kochunov, Kent E. Hutchison, Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, not Qingdao University of Science and Technology, please correct the current affiliation. Thank you, Rongtao Jiang, Dongmei Zhi, Victor M. Vergara, Xiao Yang, Daoqiang Zhang, Zening Fu, Juan Bustillo, Shile Qi, Vince D. Calhoun · 发表于：Translational Psychiatry · 年份：2024 · DOI：10.1038/s41398-024-03035-2 · 被引用次数：5 · 研究领域：Functional Brain Connectivity Studies、Attention Deficit Hyperactivity Disorder、Neurotransmitter Receptor Influence on Behavior

People affected by psychotic, depressive and developmental disorders are at a higher risk for alcohol and tobacco use. However, the further associations between alcohol/tobacco use and symptoms/cognition in these disorders remain unexplored. We identified multimodal brain networks involving alcohol use (n = 707) and tobacco use (n = 281) via supervised multimodal fusion and evaluated if these networks affected symptoms and cognition in people with psychotic (schizophrenia/schizoaffective disorder/bipolar, n = 178/134/143), depressive (major depressive disorder, n = 260) and developmental (autism spectrum disorder/attention deficit hyperactivity disorder, n = 421/346) disorders. Alcohol and tobacco use scores were used as references to guide functional and structural imaging fusion to identify alcohol/tobacco use associated multimodal patterns. Correlation analyses between the extracted brain features and symptoms or cognition were performed to evaluate the relationships between alcohol/tobacco use with symptoms/cognition in 6 psychiatric disorders. Results showed that (1) the default mode network (DMN) and salience network (SN) were associated with alcohol use, whereas the DMN and fronto-limbic network (FLN) were associated with tobacco use; (2) the DMN and fronto-basal ganglia (FBG) related to alcohol/tobacco use were correlated with symptom and cognition in psychosis; (3) the middle temporal cortex related to alcohol/tobacco use was associated with cognition in depression; ...