Influenza A(H5N1) Virus Infection in Two Dairy Farm Workers in Michigan

作者：Jennifer Morse, Joseph Coyle, Lisa Mikesell, Becky Stoddard, Seth Eckel, Meghan Weinberg, Jeremy Kuo, Diana K. Riner, Katie R. Margulieux, Jalen Stricklen, Matthew Dover, Krista Kniss, Yunho Jang, Marie K. Kirby, Julia C. Frederick, Kristine A. Lacek, C. Todd Davis, Timothy M. Uyeki, Sarah Lyon-Callo, Natasha Bagdasarian · 发表于：New England Journal of Medicine · 年份：2024 · DOI：10.1056/nejmc2407264 · 被引用次数：73 · 研究领域：Viral gastroenteritis research and epidemiology、Animal Disease Management and Epidemiology

To the Editor: In March 2024, a highly pathogenic avian influenza (HPAI) virus of A(H5N1) clade 2.3.4.4b was identified in lactating dairy cow herds in the panhandle region of Texas.As of August 1, 2024, a total of 175 herds in 13 states have been affected. 1In March 2024, a dairy farm worker in Texas had onset of conjunctivitis from infection with HPAI A(H5N1) clade 2.3.4.4b (genotype B3.13) after working with sick cows. 2 In May 2024, two adult dairy farm workers (designated as MI-A and MI-B) in Michigan were identified as having HPAI A(H5N1) virus infection.Dairy worker MI-A had discomfort in the right eye 1 day after milk had splashed in that eye while the worker was milking a cow at a farm that had confirmed HPAI A(H5N1) in dairy cows.The worker had not been using personal protective equipment.Examination on the day after symptom onset revealed mildly erythematous conjunctiva, consistent with conjunctivitis in the right eye; the left eye was unremarkable.Nasopharyngeal and conjunctival swab specimens were obtained from the right eye 1 day after symptom onset.The nasopharyngeal swab specimen that was tested at the Michigan Department of Health and Human Services (MDHHS) Bureau of Laboratories was negative for influenza viruses according to reverse-transcription-polymerasechain-reaction (RT-PCR) testing, and a BioFire FilmArray Respiratory Panel was positive for coronavirus 229E.The conjunctival and nasopharyngeal specimens were tested at the Centers for Disease Control an...