Two-dimensional nanomaterials: A multifunctional approach for robust for diabetic wound repair

作者：Mingming Cui, Jin Z. Zhang, Pengfei Han, Ling Shi, X. Li, Zhe Zhang, Haihua Bao, Yubo Ma, Ziwei Tao, Xianghui Dong, Li Fu, Yan Wu · 发表于：Materials Today Bio · 年份：2024 · DOI：10.1016/j.mtbio.2024.101186 · 被引用次数：23 · 研究领域：Graphene and Nanomaterials Applications、Carbon and Quantum Dots Applications、Nanoplatforms for cancer theranostics

Diabetic wounds pose a clinical challenge due to persistent inflammation, severe bacterial infections, inadequate vascularization, and pronounced oxidative stress. Current therapeutic modalities fail to provide satisfactory outcomes in managing these conditions, resulting in considerable patient distress. Two-dimensional nanomaterials (2DNMs), characterized by their unique nanosheet structures, expansive surface areas, and remarkable physicochemical properties, have garnered considerable attention for their potential in therapeutic applications. Emerging 2DNMs can be loaded with various pharmacological agents, including small molecules, metal ions, and liposomes. Moreover, they can be integrated with various biomaterials such as hydrogels, microneedles, and microspheres, thus demonstrating unprecedented advantages in expediting the healing process of diabetic wounds. Moreover, 2DNMs exhibit exceptional performance characteristics, including high biocompatibility, effective antimicrobial properties, optimal phototherapeutic effects, and enhanced electrostimulation capabilities. These properties enable them to modulate the wound microenvironment, leading to widespread application in tissue repair with remarkable outcomes. This review delineates several emerging 2DNMs, such as graphene and its derivatives, black phosphorus, MXenes, and transition metal dichalcogenides, in the context of diabetic wound repair. Furthermore, it elucidates the translational challenges and future per...