Prevalence and genotype distribution of human papillomavirus infection among 66000 women from 2014 to 2023 in the plateau region of Southwest China

作者：Jianpeng Hu, Junling Wang, Yun Li, Yuan Feng, Can-Qiong Tian, Guohui Zhang, Xue-Qin Chen, Hongxia Liu, Jin-Si Yang, Zhe-Wei Fang, Y.P. Li, Zongsheng Wu, Rui Zhu, Xiuping Li, Qian Xiong, Lian-Hao Gao, Ting Ji, Jian-dong Zhang, Jian-Mei Song, Qi Chen, Shumin Li, Fei He, Chunju Yang, Hongwei Li · 发表于：Virology Journal · 年份：2024 · DOI：10.1186/s12985-024-02447-2 · 被引用次数：19 · 研究领域：Cervical Cancer and HPV Research、Head and Neck Cancer Studies、Endometrial and Cervical Cancer Treatments

BACKGROUND: Persistent infection with high-risk human papillomavirus (HR-HPV) plays a key role in the onset of cervical cancer. This study was designed to examine the epidemiological trends and genotype distribution of HPV from 2014 to 2023 in the plateau region of Southwest China. METHODS: The findings could offer valuable insights for clinical screening of cervical cancer and the formulation of HPV vaccination policies. This retrospective study analyzed 66,000 women who received HPV-DNA testing at the First People's Hospital of Qujing, Yunnan, China, between 2014 and 2023. The cohort consisted of 33,512 outpatients, 3,816 inpatients, and 28,672 individuals undergoing health examinations. Cervical cells were collected for DNA extraction, and PCR amplification along with Luminex xMAP technology were used to detect 27 HPV genotypes. The data analysis was conducted using GraphPad Prism and IBM SPSS Statistics 27 software. RESULTS: The overall HPV infection rate at the First People's Hospital of Qujing declined from 24.92% in 2014 to 16.29% in 2023, averaging 16.02%. Specific infection rates were 18.50% among outpatients, 12.97% among inpatients, and 13.53% for health examination attendees. The predominant high-risk HPV genotypes identified were HPV52 (2.61%), HPV16 (2.06%), HPV58 (1.81%), HPV53 (1.55%), and HPV39 (1.09%). Meanwhile, the most frequent low-risk HPV genotypes were HPV6 (1.30%), HPV61 (1.21%), and HPV11 (0.85%). In HPV-positive cases, the distribution of single, do...