Cullin-RING Ligase 4 in Cancer: Structure, Functions, and Mechanisms

作者：Jingyi Cheng, Xin Bin, Zhangui Tang · 发表于：Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · 年份：2024 · DOI：10.1016/j.bbcan.2024.189169 · 被引用次数：12 · 研究领域：Ubiquitin and proteasome pathways、Protein Degradation and Inhibitors、Autophagy in Disease and Therapy

Cullin-RING ligase 4 (CRL4) has attracted enormous attentions because of its extensive regulatory roles in a wide variety of biological and pathological events, especially cancer-associated events. CRL4 exerts pleiotropic effects by targeting various substrates for proteasomal degradation or changes in activity through different internal compositions to regulate diverse events in cancer progression. In this review, we summarize the structure of CRL4 with manifold compositional modes and clarify the emerging functions and molecular mechanisms of CRL4 in a series of cancer-associated events.