Brain modulation after exergaming training in advanced forms of Parkinson’s disease: a randomized controlled study

作者：Anna Skrzatek, Dijana Nuic, Saoussen Cherif, Benoît Béranger, Cécile Galléa, Éric Bardinet, Marie‐Laure Welter · 发表于：Journal of NeuroEngineering and Rehabilitation · 年份：2024 · DOI：10.1186/s12984-024-01430-w · 被引用次数：10 · 研究领域：Transcranial Magnetic Stimulation Studies、Motor Control and Adaptation、Balance, Gait, and Falls Prevention

BACKGROUND: Physical activity combined with virtual reality and exergaming has emerged as a new technique to improve engagement and provide clinical benefit for gait and balance disorders in people with Parkinson's disease (PD). OBJECTIVE: To investigate the effects of a training protocol using a home-based exergaming system on brain volume and resting-state functional connectivity (rs-FC) in persons with PD. METHODS: motion sensor, while the control group played using the computer keyboard. Both groups received the same training program. Clinical scales, gait recordings, and brain MRI were performed before and after training. We assessed the effects of both training on both the grey matter volumes (GVM) and rs-FC, within and between groups. RESULTS: Twenty-three patients were enrolled and randomly assigned to either the active (n = 11) or control (n = 12) training groups. Comparing pre- to post-training, the active group showed significant improvements in gait and balance disorders, with decreased rs-FC between the sensorimotor, attentional and basal ganglia networks, but with an increase between the cerebellar and basal ganglia networks. In contrast, the control group showed no significant changes, and rs-FC significantly decreased in the mesolimbic and visuospatial cerebellar and basal ganglia networks. Post-training, the rs-FC was greater in the active relative to the control group between the basal ganglia, motor cortical and cerebellar areas, and bilaterally between the...