Metrnl: a promising biomarker and therapeutic target for cardiovascular and metabolic diseases

作者：Wen‐Sheng Dong, Can Hu, Min Hu, Yi-Peng Gao, Yuxin Hu, Kang Li, Yun-Jia Ye, Xin Zhang · 发表于：Cell Communication and Signaling · 年份：2024 · DOI：10.1186/s12964-024-01767-8 · 被引用次数：29 · 研究领域：Adipose Tissue and Metabolism、Apelin-related biomedical research、Cardiovascular Function and Risk Factors

Modern human society is burdened with the pandemic of cardiovascular and metabolic diseases. Metrnl is a widely distributed secreted protein in the body, involved in regulating glucose and lipid metabolism and maintaining cardiovascular system homeostasis. In this review, we present the predictive and therapeutic roles of Metrnl in various cardiovascular and metabolic diseases, including atherosclerosis, ischemic heart disease, cardiac remodeling, heart failure, hypertension, chemotherapy-induced myocardial injury, diabetes mellitus, and obesity.