Computed Tomography Imaging Guided Microenvironment‐Responsive Ir@WO 3−x Dual‐Catalytic Nanoreactor for Selective Radiosensitization

作者：Jiayu Song, Yue Feng, Jiazhuo Yan, Ying Wang, Weixiao Yan, Nan Yang, Tusheng Wu, Sijia Liu, Yuan Wang, Nannan Zheng, Liangcan He, Yunyan Zhang · 发表于：Advanced Science · 年份：2024 · DOI：10.1002/advs.202405192 · 被引用次数：5 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics、Advanced Photocatalysis Techniques

Abstract Radiotherapy (RT) is often administered, either alone or in combination with other therapies, for most malignancies. However, the degree of tumor oxygenation, damage to adjacent healthy tissues, and inaccurate guidance remain issues that result in discontinuation or failure of RT. Here, a multifunctional therapeutic platform based on Ir@WO 3−x is developed which simultaneously addresses these critical issues above for precision radiosensitization. Ir@WO 3−x nanoreactors exhibit strong absorption of X‐ray, acting as radiosensitizers. Moreover, ultrasmall Ir enzyme‐mimic nanocrystals (NCs) are decorated onto the surface of the nanoreactor, where NCs have catalyst‐like activity and are sensitive to H 2 O 2 in the tumor microenvironment (TME) under near infrared‐II (NIR‐II) light stimulation. They efficiently catalyze the conversion of H 2 O 2 to O 2 , thereby ameliorating hypoxia, inhibiting the expression of HIF‐1α, and enhancing RT‐induced DNA damage in cancerous tissue, further improving the efficiency of RT. Additionally, in response to high H 2 O 2 levels in TME, the Ir@WO 3−x nanoreactor also exerts peroxidase‐like activity, boosting exogenous ROS, which increases oxidative damage and enhances ROS‐dependent death signaling. Furthermore, Ir@WO 3−x can serve as a high‐quality computed tomography contrast agent due to its high X‐ray attenuation coefficient and generation of pronounced tumor‐tissue contrast. This report highlights the potential of advanced health mate...