Interplay of Food‐Derived Bioactive Peptides with Gut Microbiota: Implications for Health and Disease Management

作者：Mingyang Hu, Yufeng Du, Wenyue Li, Xiaomei Zong, Wenjuan Du, Hui‐Zeng Sun, Hongyun Liu, Ke Zhao, Jianxiong Li, Muhammad Zahid Farooq, Jianping Wu, Qingbiao Xu · 发表于：Molecular Nutrition & Food Research · 年份：2024 · DOI：10.1002/mnfr.202400251 · 被引用次数：18 · 研究领域：Protein Hydrolysis and Bioactive Peptides、Gut microbiota and health、Probiotics and Fermented Foods

Bioactive peptides (BPs) are protein fragments with beneficial effects on metabolism, physiology, and diseases. This review focuses on proteolytic BPs, which are produced by the action of gut microbiota on proteins in food and have demonstrated to influence the composition of gut microbes. And gut microbiota are candidate targets of BPs to alleviate oxidative stress, enhance immunity, and control diseases, including diabetes, hypertension, obesity, cancer, and immune and neurodegenerative diseases. Despite promising results, further research is needed to understand the mechanisms underlying the interactions between BPs and gut microbes, and to identify and screen more BPs for industrial applications. Overall, BPs offer potential as therapeutic agents for various diseases through their interactions with gut microbes, highlighting the importance of continued research in this area.