Stereoselective Construction of Trisubstituted 1,3‐Enynes via Aryl to Vinyl 1,4‐Palladium Migration

作者：Jie Lin, Juan Ma, Liandi Wang, Ping Wu, Kaikai Wu, Yong‐Gui Zhou, Zhengkun Yu · 发表于：Advanced Synthesis & Catalysis · 年份：2024 · DOI：10.1002/adsc.202400793 · 被引用次数：7 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Chemical Reactions and Isotopes

Abstract Palladium‐catalyzed stereoselective olefinic C−H alkynylation of gem ‐diarylsubstituted ethylenes with propargylic alcohols was achieved to access diverse unsymmetrical 1,3‐enynes. The regio‐ and stereoselectivities were established through a 1,4‐palladium migration from aryl to vinyl in the presence of 2‐FC 6 H 4 OH as additive. Mechanistic investigations suggest that cleavage of the olefinic C−H bond might not be involved in the rate‐determining step of the catalytic process.