Association between arteriosclerosis index and lumbar bone mineral density in U.S adults: a cross-sectional study from the NHANES 2011–2018

作者：Chengxin Xie, Ren Yu, Qiang He, Chenglong Wang, Hua Luo · 发表于：Frontiers in Cardiovascular Medicine · 年份：2024 · DOI：10.3389/fcvm.2024.1459062 · 被引用次数：8 · 研究领域：Bone health and osteoporosis research、Vitamin K Research Studies、Bone Metabolism and Diseases

Background The arteriosclerosis index, defined as the ratio of non-high density lipoprotein cholesterol to high density lipoprotein cholesterol (NHHR), has emerged as a novel biomarker for various diseases. The relationship between NHHR and lumbar bone mineral density (BMD) has not been previously examined. Methods This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. NHHR was calculated as (total cholesterol—high-density lipoprotein cholesterol)/high-density lipoprotein cholesterol. Lumbar BMD was calculated to Z scores. Weighted multivariate linear regression, subgroup analysis, interaction analysis, generalized additive model, and two-piecewise linear regression were used. Results A total of 8,602 participants were included. The negative association between NHHR and lumbar BMD was consistent and significant (Model 1: β = −0.039, 95% CI: −0.055, −0.023, p < 0.001; Model 2: β = −0.045, 95% CI: −0.062, −0.027, p < 0.001; Model 3: β = −0.042, 95% CI: −0.061, −0.023, p < 0.001). The linear relationship between NHHR and lumbar BMD was significantly influenced by body mass index ( p for interaction = 0.012) and hypertension ( p for interaction = 0.047). Non-linear associations between NHHR and lumbar BMD Z scores were observed in specific populations, including U-shaped, reverse U-shaped, L-shaped, reverse L-shaped, and U-shaped relationships among menopausal females, underweight participants, t...