RPRD1B/CREPT facilitates the progression of diffuse large B-cell lymphoma by inhibiting apoptosis through the NF-κB signaling pathway

作者：Lu Xu, Zhihao Xie, Jun Li, Shi Tao, Fangli Ren, Yinyin Wang, Zhijie Chang, Xinbao Hao · 发表于：Asian Pacific Journal of Tropical Biomedicine · 年份：2024 · DOI：10.4103/apjtb.apjtb_172_24 · 被引用次数：1 · 研究领域：Lymphoma Diagnosis and Treatment、Ubiquitin and proteasome pathways、RNA Research and Splicing

Objective: To investigate the role of RPRD1B in the progression of diffuse large B-cell lymphoma (DLBCL) and its potential as a therapeutic target. Methods: This study analyzed RPRD1B expression in DLBCL and normal tissues using public databases and assessed its prognostic impact through survival analysis. In vitro and in vivo experiments were conducted to explore the mechanisms by which RPRD1B influences tumor growth and apoptosis. Results: RPRD1B expression was significantly elevated in DLBCL compared to normal tissues and was associated with poor prognosis. In vitro and in vivo experiments demonstrated that RPRD1B promoted lymphoma cell proliferation and inhibited apoptosis through the NF-κB signaling pathway. Conclusions: RPRD1B plays a critical role in the progression of DLBCL by modulating apoptosis and cellular proliferation. Targeting RPRD1B may offer a novel therapeutic strategy for DLBCL, suggesting its potential as a prognostic marker and therapeutic target in hematological malignancies.