Limited transmission of carbapenem-resistant Klebsiella pneumoniae between animals and humans: a study in Qingdao

作者：Rina Bai, Xiao Wang, Zhiyu Zou, Wenjing Zhou, Chang Tan, Yue Cao, Bo Fu, Weishuai Zhai, Fupin Hu, Yang Wang, Congming Wu, Yuanqi Zhu, Chengtao Sun · 发表于：Emerging Microbes & Infections · 年份：2024 · DOI：10.1080/22221751.2024.2387446 · 被引用次数：12 · 研究领域：Antibiotic Resistance in Bacteria、Escherichia coli research studies、Vibrio bacteria research studies

Despite no carbapenem use in food animals, carbapenem-resistant Klebsiella pneumoniae (CRKP) perseveres within food animals, rising significant concerns regarding public health risks originating from these non-clinical reservoirs. To investigate the potential link between CRKP in food animals and its infections in humans, we conducted a cross-sectional study encompassing human clinical, meat products, and farm animals, in Qingdao city, Shandong province, China. We observed a relatively higher presence of CRKP among hospital inpatients (7.3%) compared to that in the meat products (2.7%) and farm animals (pig, 4.6%; chicken, 0.63%). Multilocus sequence typing and core-genome phylogenetic analyses confirm there is no evidence of farm animals and meat products in the clinical acquisition of K. pneumoniae isolates and carbapenem-resistant genes. However, potential transmission of K. pneumoniae of ST659 and IncX3 plasmid harbouring blaNDM-5 gene from pigs to pork and farm workers was observed. Our findings suggest a limited role of farm animals and meat products in the human clinical acquisition of K. pneumoniae, and the transmission of K. pneumoniae is more common within settings, than between them.