Safety and efficacy of Withania somnifera for anxiety and insomnia: Systematic review and meta‐analysis

作者：Kaneez Fatima, Javeria Malik, Fnu Muskan, Ghana Raza, Areesha Waseem, Hiba Shahid, Syeda Fatima Jaffery, Umeed Ali Khan, Muhammad Kashan Zaheer, Yasmeen Shaikh, Ahmed Mustafa Rashid · 发表于：Human Psychopharmacology Clinical and Experimental · 年份：2024 · DOI：10.1002/hup.2911 · 被引用次数：13 · 研究领域：Phytochemicals and Medicinal Plants、Mindfulness and Compassion Interventions、Piperaceae Chemical and Biological Studies

OBJECTIVE: Despite the historical neurological use of Withania somnifera, limited evidence supports its efficacy for conditions like anxiety and insomnia. Given its known anti-stress properties, this review evaluated its safety and efficacy for anxiety and insomnia. METHODS: We searched Medline, Cochrane Library, and Google Scholar until August 2023 for randomized controlled trials (RCTs) comparing W. somnifera to placebo in patients with anxiety and/or insomnia. Outcome measures included changes in anxiety levels via the Hamilton Anxiety Scale (HAM-A), Sleep Onset Latency (SOL), Total Sleep Time (TST), Wake After Sleep Onset (WASO), Total Time in Bed (TIB), Sleep Efficiency (SE), and Pittsburgh Sleep Quality Index (PSQI) score. We utilized a random-effect model for pooling Mean Differences (MD) with a 95% Confidence Interval (CI). Heterogeneity was assessed through sensitivity and subgroup analysis, and the quality of RCTs was evaluated using the Cochrane revised risk of bias tool. RESULTS: = 98%), as well as sleep parameters such as SOL, TST, PSQI, and SE, but not WASO and TIB. CONCLUSION: While W. somnifera extracts yielded promising results, further research with larger sample sizes is needed to confirm its effects on anxiety and insomnia.