Bisphenol mixtures, metal mixtures and type 2 diabetes mellitus: Insights from metabolite profiling

作者：Ze Yang, Hongbo Liu, Jiemin Wei, Ruifang Liu, Jingyun Zhang, Meiqing Sun, Changkun Shen, Jian Liu, Kun Men, Yu Chen, Xueli Yang, Pei Yu, Liming Chen, Naijun Tang · 发表于：Environment International · 年份：2024 · DOI：10.1016/j.envint.2024.108921 · 被引用次数：12 · 研究领域：Effects and risks of endocrine disrupting chemicals、Metabolomics and Mass Spectrometry Studies、Health, Environment, Cognitive Aging

BACKGROUND: Little is known about the combined effect of bisphenol mixtures and metal mixtures on type 2 diabetes mellitus (T2DM) risk, and the mediating roles of metabolites. METHODS: The study included 606 pairs of T2DM cases and controls matched by age and sex, and information of participants was collected through questionnaires and laboratory tests. Serum bisphenol and plasma metal concentrations were measured using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS) and inductively coupled plasma-mass spectrometry (ICP-MS), respectively. Widely targeted metabolomics was employed to obtain the serum metabolomic profiles. Conditional logistic regression models were used to assess the single associations of bisphenols and metals with T2DM risk after multivariable adjustment. Additionally, the joint effects of bisphenol mixtures and metal mixtures were examined using quantile-based g-computation (QG-C) models. Furthermore, differential metabolites associated with T2DM were identified, and mediation analyses were performed to explore the role of metabolites in the associations of bisphenols and metals with T2DM risk. RESULTS: The results showed bisphenol mixtures were associated with an increased T2DM risk, with bisphenol A (BPA) identified as the primary contributor. While the association between metal mixtures and T2DM remained inconclusive, cobalt (Co), iron (Fe), and zinc (Zn) showed the highest weight indices for T2DM risk. A total of 154 differential ...