Genetic diversity of United States Rambouillet, Katahdin and Dorper sheep

作者：Gabrielle M. Becker, Jacob W Thorne, J.M. Burke, Ronald M Lewis, D. R. Notter, James L. Morgan, C. S. Schauer, Whit C Stewart, R. R. Redden, Brenda M. Murdoch · 发表于：Genetics Selection Evolution · 年份：2024 · DOI：10.1186/s12711-024-00905-7 · 被引用次数：13 · 研究领域：Genetic and phenotypic traits in livestock、Genetic Mapping and Diversity in Plants and Animals、Cancer-related molecular mechanisms research

Abstract Background Managing genetic diversity is critically important for maintaining species fitness. Excessive homozygosity caused by the loss of genetic diversity can have detrimental effects on the reproduction and production performance of a breed. Analysis of genetic diversity can facilitate the identification of signatures of selection which may contribute to the specific characteristics regarding the health, production and physical appearance of a breed or population. In this study, breeds with well-characterized traits such as fine wool production (Rambouillet, N = 745), parasite resistance (Katahdin, N = 581) and environmental hardiness (Dorper, N = 265) were evaluated for inbreeding, effective population size ( N e ), runs of homozygosity (ROH) and Wright’s fixation index (F ST ) outlier approach to identify differential signatures of selection at 36,113 autosomal single nucleotide polymorphisms (SNPs). Results Katahdin sheep had the largest current N e at the most recent generation estimated with both the GONe and NeEstimator software. The most highly conserved ROH Island was identified in Rambouillet with a signature of selection on chromosome 6 containing 202 SNPs called in an ROH in 50 to 94% of the individuals. This region contained the DCAF16 , LCORL and NCAPG genes that have been previously reported to be under selection and have biological roles related to milk production and growth traits. The outlier regions identified through the F ST comparisons of Kat...