Untargeted metabolomics study of mature human milk from women with and without gestational diabetes mellitus

作者：Dan Yao, Cai Shen, Xinghe Zhang, Jiayue Tang, Jingwen Yu, Maolin Tu, Worawan Panpipat, Manat Chaijan, Hong Zhang, Xuebing Xu, Yanan Liu, Ling‐Zhi Cheong · 发表于：Food Chemistry · 年份：2024 · DOI：10.1016/j.foodchem.2024.140663 · 被引用次数：13 · 研究领域：Gestational Diabetes Research and Management、Infant Nutrition and Health、Breastfeeding Practices and Influences

Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder during pregnancy that alters the metabolites in human milk. Integrated Gas Chromatography-Mass Spectrometry (GC-MS) and Liquid Chromatography-Mass Spectrometry (LC-MS) were employed for comprehensive identification and comparison of metabolites in mature human milk (MHM) from women with and without GDM. A total of 268 differentially expressed metabolites (DEMs) were identified. Among these, linoleic acid, arachidonic acid, 9R-HODE and L-glutamic acid were significantly elevated and 12,13-DHOME was significantly decreased in MHM of women with GDM. These metabolites are significantly enriched in linoleic acid metabolism, fatty acid biosynthesis, galactose metabolism and ABC transporters pathways. Disorders in these metabolic pathways are associated with insulin resistance and poor glucose metabolism indicating these conditions may persist postpartum.