Unveiling the phytochemical profile and biological potential of five Dendrobium species

作者：Lingxia Peng, Jiani Yu, Jiahao Fang, Feng Yin, G. Abirami, Jianxiong Wu, Ganggui Lou, Hongju Li, Lijun Yang, Jie Xia, Dongfeng Yang, Zongsuo Liang, Xiaodan Zhang · 发表于：Arabian Journal of Chemistry · 年份：2024 · DOI：10.1016/j.arabjc.2024.105922 · 被引用次数：11 · 研究领域：Biological and pharmacological studies of plants、Phytochemistry and Biological Activities、Bioactive natural compounds

Dendrobium, a genus of orchids celebrated for their ornamental, medicinal, and culinary uses, is the focus of this study, which examines the metabolite profiles and bioactivity of five species: Dendrobium officinale, Dendrobium nobile, Dendrobium crepidatum, Dendrobium chrysotoxum, and Dendrobium denneanum. Utilizing UPLC-Q-TOF-MSE analysis, we have identified 88 compounds from the stems and leaves of these species. Notably, extracts from D. denneanum and D. chrysotoxum exhibited the highest antioxidant activities as demonstrated by DPPH, ABTS radical scavenging, and FRAP assays. Additionally, D. officinale showed significant anti-hepatoma activity with an IC50 value of 104 μg/mL. Multivariate analysis, hierarchical cluster analysis, and metabolites correlation analysis further elucidated the bioactive potential of these species. This comprehensive approach revealed distinct metabolite profiles that correlate with the observed bioactivities. The antioxidant activities of D. denneanum and D. chrysotoxum were particularly noteworthy, suggesting their potential as natural sources of antioxidants for pharmaceutical and nutraceutical applications. The anti-hepatoma activity of D. officinale, with its notable IC50 value, indicates its promise as a therapeutic agent against liver cancer. The findings underscore the richness of bioactive compounds in Dendrobium species, highlighting their antioxidant and anti-hepatoma properties. These insights pave the way for further research into ...