Effect of prenatal phthalate exposure on fetal development and maternal/neonatal health consequences: A systematic review

作者：Laura Almeida-Toledano, Elisabet Navarro‐Tapia, Giorgia Sebastiani, Silvia Ferrero-Martínez, Patricia Ferrer-Aguilar, Óscar García‐Algar, Vicente Andreu-Férnández, María Dolores Gómez‐Roig · 发表于：The Science of The Total Environment · 年份：2024 · DOI：10.1016/j.scitotenv.2024.175080 · 被引用次数：55 · 研究领域：Effects and risks of endocrine disrupting chemicals

The ubiquitous presence of phthalate compounds in cosmetics, personal care products and plastics commonly used in toys, food packaging or household products, results in human exposure with adverse effects on reproductive health and fetal development. Following the PRISMA methodology, this systematic review analyzes the effect of prenatal phthalate exposure on major pregnancy complications, such as gestational diabetes, pregnancy-induced hypertension, fetal growth restriction and preterm birth, and its role in fetal neurodevelopment. This review includes >100 articles published in the last 10 years, showing an association between maternal exposure to phthalates and the risk of developing pregnancy complications. Phthalates are negatively associated with motor skills and memory, and also increase the risk of delayed language acquisition, autism spectrum disorder traits, and behavioral deficits, such as attention deficit hyperactivity disorder in children prenatally exposed to phthalates. Di (2-ethylhexyl) phthalate and its metabolites (mono(2-ethylhexyl) phthalate, mono(3-carboxypropyl) phthalate, mono(2-ethyl-5-hydroxyhexyl) phthalate, mono(2-ethyl-5-oxohexyl) phthalate) are the main compounds associated with the above-mentioned pregnancy complications and fetal neurodevelopmental disorders. In addition, this review discusses the molecular mechanisms responsible for various pregnancy complications and neurodevelopmental disorders, and the critical window of exposure, in order ...