Difficult to treat Pseudomonas: successful salvage therapy with cefepime-zidebactam

作者：Anjely Sebastian, Shivdas Naik, Muralidhar Varma, N C Sreekumar, Joseph Thomas, Tanvi Rao, B Shah, Nitin Gupta · 发表于：Transactions of the Royal Society of Tropical Medicine and Hygiene · 年份：2024 · DOI：10.1093/trstmh/trae049 · 被引用次数：9 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotics Pharmacokinetics and Efficacy、Antibiotic Use and Resistance

Carbapenem-resistant Pseudomonas aeruginosa (CRPa) infection is extremely challenging to manage. Cefepime-zidebactam is a novel combination that can be considered for salvage therapy when no other antimicrobials are susceptible. A 15-y-old boy presented with 56% thermal burns, followed by skin and soft tissue infection, secondary bacteraemia, complicated parapneumonic effusion and endophthalmitis due to CRPa, which was not susceptible to any of the routinely available antibiotics. He was treated with cefepime-zidebactam for 45 d, with which he recovered.