Concise syntheses of (+)-maximumins B and C and (+)-ottensinin

作者：Qingxin Li, Linlin Wang, Yueming Zheng, Zhaobing Gao, Jin‐Xin Zhao, Jian‐Min Yue · 发表于：Organic Chemistry Frontiers · 年份：2024 · DOI：10.1039/d4qo00878b · 被引用次数：7 · 研究领域：Natural product bioactivities and synthesis、Bioactive Compounds and Antitumor Agents、Traditional and Medicinal Uses of Annonaceae

Three rearranged labdane diterpenoids, featuring a common 3-substituted γ-pyrone, were effectively synthesized with the longest linear sequences of 4–12 steps. The in-depth pharmacological screening unveiled (+)-ottensinin as a potent KCNQ2 agonist.