Copper Single-Atom-Based Metal–Organic Framework for Ultrasound-Enhanced Nanocatalytic Therapy

作者：He Wang, Zhiping Zhang, Xiao Wang, Xinxin Jin, Xing Gao, Lei Yu, Quanxiang Han, Zhao Wang, Jibin Song · 发表于：Nano Letters · 年份：2024 · DOI：10.1021/acs.nanolett.4c02246 · 被引用次数：28 · 研究领域：Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis、Nanocluster Synthesis and Applications

Chemodynamic therapy (CDT) is an emerging therapeutic modality triggered by endogenous substances in the tumor microenvironment (TME) to generate reactive oxygen species. However, the mild acid pH, low H 2 O 2 concentration, and overexpressed glutathione can suppress the CDT efficiency. Herein, ultrasound (US)-triggered Cu 2+ -based single-atom nanoenzymes (FA-NH 2 -UiO-66-Cu, FNUC) are constructed with the performance of target and glutathione depletion. In the TME, the single-atom Cu sites of FNUC consume glutathione and the FNUC:Cu + generates •OH via peroxidase-like activity. The US-activated FNUC exhibits a fast •OH generation rate, a low Michaelis constant, and a large •OH concentration, indicating the cavitation effect of US promotes the •OH generation. Meanwhile, the tumor target of FNUC is confirmed by NIR-II fluorescence imaging, in which it is modified with IR-1061. Combined with the antitumor performance of FNUC in vitro and in vivo, the novel Cu-based SAzymes can achieve efficient and precise cancer treatment.