Experiencing anesthesia and surgery early in life impairs cognitive and behavioral development

作者：Xuqin Jia, Siyou Tan, Yinying Qin, Yi Wei, Yage Jiang, Sining Pan, Chunlai Li, Jing Chen, Tianxiao Liu, Yubo Xie · 发表于：Frontiers in Neuroscience · 年份：2024 · DOI：10.3389/fnins.2024.1406172 · 被引用次数：9 · 研究领域：Anesthesia and Neurotoxicity Research、Intensive Care Unit Cognitive Disorders、Pediatric Pain Management Techniques

Background: The impact of anesthesia and surgery on neurocognitive and behavioral development in infants and children remains inadequately understood. Objective: To investigate the impact of early-life exposure to general anesthesia and surgery on cognitive and behavioral development. Methods and materials: Children aged 0-3 years who underwent general anesthesia and surgical procedures between 2012 and 2015 were included. The cognitive and behavioral development of these children at ages 4-6 years was assessed. Age-, race-, and gender-matched children from the same geographic region, who did not undergo general anesthesia or surgery, served as the control group. The Wechsler Preschool Primary Scale of Intelligence, Fourth Edition (WPPSI-IV) was used to evaluate children's total intelligence quotient (FSIQ) and specific cognitive domains. The Gesell Development Schedules (GSCH) and Child Behavior Checklist (CBCL) were employed to assess behavioral and personality development. Additionally, the study analyzed the effects of various factors including anesthesia drugs, surgery duration, number of surgeries, age, weight, ethnicity, and gender on postoperative neurocognitive and behavioral outcomes. Results: < 0.05). Exploratory findings indicated that children administered remifentanil exhibited lower developmental quotient (DQ) values, whereas those given fentanyl showed higher (worse) Child Behavior Checklist (CBCL) total scores. Moreover, increased anesthesia/surgical exposure...