New Insights into the Use of Traditional Chinese Medicine for Treating Diabetic Kidney Disease by Regulating DNA Methylation

作者：Liang Ma, Ziyi Feng, Ping Li · 发表于：Integrative Medicine in Nephrology and Andrology · 年份：2024 · DOI：10.1097/imna-d-24-00018 · 被引用次数：21 · 研究领域：Dietary Effects on Health、Traditional Chinese Medicine Studies、Cancer-related molecular mechanisms research

INTRODUCTION The prevalence of diabetes mellitus (DM) is increasing annually. The International Diabetes Federation reported that the global diabetic population reached 463 million in 2019 and is projected to rise to 700 million by 2045.[1] Diabetic kidney disease (DKD) —a major chronic complication of DM—is the primary cause of end-stage renal disease (ESRD).[2] Consequently, elucidating the pathogenesis of DKD and identifying effective treatments to prevent its progression to ESRD are critical. The etiology of DKD is multifaceted, involving inflammation, oxidative stress, and lipid metabolic disorders, among others. Although DKD exhibits a degree of heritability, this does not fully account for its development in all cases. Enhancing our understanding of DKD’s molecular mechanisms could pave the way for more effective clinical interventions to manage and prevent this complication. Previous studies have demonstrated that DKD can develop even when blood glucose levels are well controlled—a phenomenon known as “metabolic memory”.[2] Research into metabolic memory has increasingly focused on the epigenetic regulation of DNA methylation, histone modification, and noncoding RNA (ncRNA). DNA methylation—the most extensively studied epigenetic mechanism in DKD—plays a critical role in gene expression regulation and chromosomal stability. Investigating epigenetic alterations in DKD is crucial for developing targeted treatments. Traditional Chinese medicine (TCM), characterized by it...