Vagus Nerve and Gut-Brain Communication

作者：Yiyang Wang, Chenxi Duan, Xinyi Du, Ying Zhu, Lihua Wang, Jun Hu, Yanhong Sun · 发表于：The Neuroscientist · 年份：2024 · DOI：10.1177/10738584241259702 · 被引用次数：25 · 研究领域：Vagus Nerve Stimulation Research、Heart Rate Variability and Autonomic Control、Neuroscience of respiration and sleep

The vagus nerve, as an important component of the gut-brain axis, plays a crucial role in the communication between the gut and brain. It influences food intake, fat metabolism, and emotion by regulating the gut-brain axis, which is closely associated with the development of gastrointestinal, psychiatric, and metabolism-related disorders. In recent years, significant progress has been made in understanding the vagus-mediated regulatory pathway, highlighting its profound implications in the development of many diseases. Here, we summarize the latest advancements in vagus-mediated gut-brain pathways and the novel interventions targeting the vagus nerve. This will provide valuable insights for future research on treatment of obesity and gastrointestinal and depressive disorders based on vagus nerve stimulation.