Cortical Morphological Networks Differ Between Gyri and Sulci

作者：Qingchun Lin, Suhui Jin, Guole Yin, Junle Li, Umer Asgher, Shijun Qiu, Jinhui Wang · 发表于：Neuroscience Bulletin · 年份：2024 · DOI：10.1007/s12264-024-01262-7 · 被引用次数：8 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Mental Health Research Topics

This study explored how the human cortical folding pattern composed of convex gyri and concave sulci affected single-subject morphological brain networks, which are becoming an important method for studying the human brain connectome. We found that gyri-gyri networks exhibited higher morphological similarity, lower small-world parameters, and lower long-term test-retest reliability than sulci-sulci networks for cortical thickness- and gyrification index-based networks, while opposite patterns were observed for fractal dimension-based networks. Further behavioral association analysis revealed that gyri-gyri networks and connections between gyral and sulcal regions significantly explained inter-individual variance in Cognition and Motor domains for fractal dimension- and sulcal depth-based networks. Finally, the clinical application showed that only sulci-sulci networks exhibited morphological similarity reductions in major depressive disorder for cortical thickness-, fractal dimension-, and gyrification index-based networks. Taken together, these findings provide novel insights into the constraint of the cortical folding pattern to the network organization of the human brain.