Research progress of T cell autophagy in autoimmune diseases

作者：Xingxing Zhao, Dan Ma, Baoqi Yang, Yajing Wang, Liyun Zhang · 发表于：Frontiers in Immunology · 年份：2024 · DOI：10.3389/fimmu.2024.1425443 · 被引用次数：7 · 研究领域：Autophagy in Disease and Therapy、Calcium signaling and nucleotide metabolism、Immune Cell Function and Interaction

T cells, as a major lymphocyte population involved in the adaptive immune response, play an important immunomodulatory role in the early stages of autoimmune diseases. Autophagy is a cellular catabolism mediated by lysosomes. Autophagy maintains cell homeostasis by recycling degraded cytoplasmic components and damaged organelles. Autophagy has a protective effect on cells and plays an important role in regulating T cell development, activation, proliferation and differentiation. Autophagy mediates the participation of T cells in the acquired immune response and plays a key role in antigen processing as well as in the maintenance of T cell homeostasis. In autoimmune diseases, dysregulated autophagy of T cells largely influences the pathological changes. Therefore, it is of great significance to study how T cells play a role in the immune mechanism of autoimmune diseases through autophagy pathway to guide the clinical treatment of diseases.