Uric acid mediates the relationship between mixed heavy metal exposure and renal function in older adult people

作者：Sai Yi Pan, Yue Niu, Shuwei Duan, Delong Zhao, Qian Wang, Zheyi Dong, Guangyan Cai, Xiangmei Chen · 发表于：Frontiers in Public Health · 年份：2024 · DOI：10.3389/fpubh.2024.1403878 · 被引用次数：13 · 研究领域：Heavy Metal Exposure and Toxicity、Heavy Metals in Plants、Trace Elements in Health

Background: Population aging is a pivotal trend observed globally, and the exposure to heavy metals can exacerbate the aging process and lead to kidney damage. However, the impact of combined heavy metal exposure on renal function among older individuals remains elusive. Our study employs machine learning techniques to delve into the effects and underlying mechanisms of mixed exposure to heavy metals on the renal function of the aging population. Methods: This study extracted comprehensive data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2015 and 2020. A total of 3,175 participants aged 60 years and above, with complete information on six metals - lead, cadmium, manganese, cobalt, mercury, and selenium, along with relevant covariates, were included in the study. To assess the impact of single or mixed metal exposure on the renal function of older adult individuals, various statistical techniques were employed: multiple logistic regression, weighted quantitative sum (WQS) regression, Bayesian kernel machine regression (BKMR), and mediation effects analysis. Results: Multiple logistic regression revealed that selenium and manganese were protective factors for chronic kidney disease (CKD). Cobalt was a risk factor for CKD. High concentrations of lead, cadmium, and cobalt were risk factors for urinary albumin creatinine ratio (ACR). WQS analyses revealed that mixed metal exposure was positively correlated with estimated glomerular filtrati...