Self‐Gated Radial Free‐Breathing Liver MR Elastography: Assessment of Technical Performance in Children at 3 T

作者：Sevgi Gökçe Kafalı, Bradley D. Bolster, Shu‐Fu Shih, Timoteo Delgado, Vibhas Deshpande, Xiaodong Zhong, Timothy Adamos, Shahnaz Ghahremani, Kara L. Calkins, Holden H. Wu · 发表于：Journal of Magnetic Resonance Imaging · 年份：2024 · DOI：10.1002/jmri.29541 · 被引用次数：3 · 研究领域：Liver Disease Diagnosis and Treatment、Ultrasound Imaging and Elastography、Hepatocellular Carcinoma Treatment and Prognosis

BACKGROUND: Conventional liver magnetic resonance elastography (MRE) requires breath-holding (BH) to avoid motion artifacts, which is challenging for children. While radial free-breathing (FB)-MRE is an alternative for quantifying liver stiffness (LS), previous methods had limitations of long scan times, acquiring two slices in 5 minutes, and not resolving motion during reconstruction. PURPOSE: To reduce FB-MRE scan time to 4 minutes for four slices and to investigate the impact of self-gated (SG) motion compensation on FB-MRE LS quantification in terms of agreement, intrasession repeatability, and technical quality compared to conventional BH-MRE. STUDY TYPE: Prospective. POPULATION: Twenty-six children without fibrosis (median age: 12.9 years, 15 females). FIELD STRENGTH/SEQUENCE: 3 T; Cartesian gradient-echo (GRE) BH-MRE, research application radial GRE FB-MRE. ASSESSMENT: Participants were scanned twice to measure repeatability, without moving the table or changing the participants' position. LS was measured in areas of the liver with numerical confidence ≥90%. Technical quality was examined using measurable liver area (%). STATISTICAL TESTS: Agreement of LS between BH-MRE and FB-MRE was evaluated using Bland-Altman analysis for SG acceptance rates of 40%, 60%, 80%, and 100%. LS repeatability was assessed using within-subject coefficient of variation (wCV). The differences in LS and measurable liver area were examined using Kruskal-Wallis and Wilcoxon signed-rank tests. P...