The Role and Mechanism of Autoantibodies in Dysimmunity Related Neurological Diseases

作者：Yongchao Xu, Wenshan Zhao, Jiali Shan, Yi Zhang, Yuqing Gong, Leping Wang, Jialu Ye, Jiawen Dong, Yalun Chen, Yuyang Ye, Keting Jin, Jinhui Hong, Qiang Ke, Kaibo Zhang · 发表于：Journal of Experimental Neurology · 年份：2024 · DOI：10.33696/neurol.5.094 · 研究领域：Autoimmune Neurological Disorders and Treatments、Diabetes and associated disorders、Monoclonal and Polyclonal Antibodies Research

Autoantibodies are antibodies produced by B cells capable of attacking their own tissues or organs after loss of immune tolerance. A large body of literature shows that autoantibodies play an important role in neurological diseases associated with immune abnormalities. Nowadays, neurological disorders are an important cause of disability and death in populations around the world, so it is important to study the role and mechanisms of autoantibodies in neurological disorders associated with immune abnormalities. The blood-brain barrier is biologically important for maintaining the normal physiological state of the central nervous system, and we have previously found that monoclonal autoantibodies of SLE origin can inhibit the expression of tight junction proteins in the blood-brain barrier. Our findings provide clues for the study of the role of autoantibodies in neurological disorders and greatly attract us to conduct a more in-depth and systematic review and synthesis. In this paper, we summarize the functions of autoantibodies in autoimmune and non-autoimmune diseases and focus on the roles and mechanisms of autoantibodies in immune-associated neurological disorders by taking central and peripheral neurological diseases as the entry points, which can provide new molecular targets and new theoretical basis for the specific diagnosis and targeted therapy of neurological diseases.