Maternal Hypertensive Disorder in Pregnancy and Childhood Strabismus in Offspring

作者：Hui Zhu, Xue Yi You, Jing Yu, Yiyuan Chen, Yangqian Jiang, Yuan Lin, Tao Jiang, Rui Qin, Hong Lv, Qun Lü, Cong Liu, Xin Xu, Yuxin Liu, Tian‐Yu Sun, Mengting Jiang, Bo Xu, Xiumei Han, Jiaping Chen, Yue Jiang, Xiaoyu Liu, Kun Zhou, Guangfu Jin, Hongxia Ma, Zhibin Hu, Hu Liu, Jiangbo Du, China National Birth Cohort Study Group, Hongbing Shen, Yankai Xia, Jiong Li, Chuncheng Lu, Yang Zhao, Wei Wu, Minjian Chen, Shanshan Geng, Ding Ye, Lei Huang, Shiyao Tao, Yuanyan Dou, Shuifang Lei, Ke Kang, Yanjie Zhang, Yiqun Xu, Jinghan Wang, Xianxian Zhu, Huixin Xue, Ming Gan, Shuxin Xiao, Weiting Wang, Di Pi, Chang Wang, Haowen Zhang, Bo Yang, Yufan Jin, Xiao Zhang, Yongbin Xiong, Xin Zou, Zheng Yong, Shuting Wu, Yue Qu, Qin Wang, Jie Chen, Ganchong Liao, Liya Pang, Dan Huang, Zhujun Fu, Zijin Wang, Yue Wang, Rui Li, Haohai Tong, Shu Han, Xiaoyan Zhao, Shiya Shen, Yun Wang, Yan Wen, Xiaoxiao Li, Andi Zhao, Danni Chen, Lei Liu, Wei Guo, Yingxiao Qian, Lei Hua, Qi Yan, Xiaoxia Zuo, Tong Zhang, Ziyi Ni, Jing Yu, Tiantian Zhou, Xiaoqi Zhu, Chenyu Zhou, Yuting Zhang, Yunfan Shi, Yuhong Feng, Chuxuan Zhang, Haodong Chi, Fanbo Sun, Jian Cui, Yan Gao, Xinyuan Yao, Meng Li, Jiahao Si, Shasha Xu, Xi Chen, Jiyu Zhang, Xinyu Zheng, Yelongzi Cao, Xiaodong Shao, Shuning Liu, Yuxi Chen, Shu Qin, Shiding Li, Jingsong Dang, Tao Zhang, Ranran Ding, Yuemin Wu, Liyuan Wang, Ningjing Zhao, Jiajia Yang, Shuoyang Zhao, Yichao Qian, Yao Lu, Yue Zhu, Fanfei Ma, Changqin Zhang, Yuxiao Xu, Yan Zhu, Weiyi Dong, Mengqi Dong, Zhitong Li, Jun Sun, Y. Yi, Hongxue Fu, Jie Dou, Wanting Gao, Zhuorong Li, Leyan Sun, Lan Tang, Xinyan Xu, H. J. Yang, Ping Xue, Shengxiang Huang, Yidan Xia, Sirui Gu, Yaxin Chen, Yizheng Zhang, Qi Chen, Ruize Wu, Anqi Shi, Yujie Jiang, Rui‐Hua Xu, Linting Mei, Xuexian Zhu, Yiting Wang, Xianyue Liang, Jing Xu, Zheng Zhang, Chengfei Xu, Jin Liu, Yucao Wang, Jinghan Liang, Jiaxu Li, Junyi You, Zhiying Lin, Wenjie Zhou, Zihan Yin, Cheng Sun, Difei Zuo, Ruini Zhu, Qikun Deng, Yujiao Shi, Yujie Wang, Zhen Wang, Xiaoyu Fan, Xinying Li · 发表于：JAMA Network Open · 年份：2024 · DOI：10.1001/jamanetworkopen.2024.23946 · 被引用次数：8 · 研究领域：Pregnancy and preeclampsia studies、Ophthalmology and Eye Disorders、Cerebral Venous Sinus Thrombosis

Importance: Maternal hypertensive disorder in pregnancy (HDP) might affect ocular health in offspring; however, its association with strabismus remains unclear. Objective: To examine the association of maternal HDP with overall and type-specific strabismus in offspring. Design, Setting, and Participants: In the Jiangsu Birth Cohort study, a population-based study in China, pregnant women were recruited from April 24, 2014, to November 30, 2018. A total of 6195 offspring had maternal HDP diagnosis information, of whom 3078 were excluded due to having no information on ocular alignment or due to having ocular diseases other than strabismus or refractive error. Offspring underwent ocular examinations at 3 years of age, completed May 21, 2022. Data were analyzed from May 28, 2022, through December 15, 2023. Exposure: Maternal HDP, categorized into hypertension and preeclampsia or with blood pressure (BP) well controlled (systolic BP, <130; diastolic BP, <80 mm Hg) and poorly controlled (systolic BP, ≥130; diastolic BP, ≥80 mm Hg). Main Outcomes and Measures: The primary outcome was the incidence of strabismus in offspring. Poisson generalized linear mixed models were used to estimate the association between maternal HDP and strabismus. Results: Among the included 3117 children (mean [SD] age, 36.30 [0.74] months; 1629 boys [52.3%]), 143 (4.6%) were exposed to maternal HDP and 368 (11.8%) had strabismus. Offspring exposed to maternal HDP had an 82% increased risk of overall strabi...