Base-Promoted Annulated Aromatization of Aryl Acetylenes with Dimethyl Sulfoxide to Access Symmetrical/Unsymmetric m -Terphenyl

作者：Wenli Zhu, Niu Tang, Wenjun Zhou, Cheng-Han Li, Yifeng Ou, Ablimit Abdukader, Renhua Qiu · 发表于：The Journal of Organic Chemistry · 年份：2024 · DOI：10.1021/acs.joc.4c00790 · 被引用次数：9 · 研究领域：Chemical Synthesis and Reactions、Catalytic Cross-Coupling Reactions、Synthesis and Characterization of Pyrroles

A protocol for selective and efficient synthesis of symmetrical and unsymmetrical m -terphenyls is presented among aryl acetylene and DMSO in the presence of KOH and methanol. In this reaction, two molecules of aryl acetylene contribute four carbons, and DMSO, as a dual carbon donor, provides two carbons to a new aromatic ring. This protocol can be tolerated for the electron-donating or disubstituted phenylacetylenes as well as the heterocyclic acetylene derivatives.