Spicy food consumption and risk of vascular disease: Evidence from a large-scale Chinese prospective cohort of 0.5 million people

作者：Dongfang You, Dianjianyi Sun, Ziyu Zhao, Mingyu Song, Lulu Pan, Yaqian Wu, Yingdan Tang, Mengyi Lu, Fang Shao, Sipeng Shen, Jianling Bai, Honggang Yi, Ruyang Zhang, Yongyue Wei, Hongxia Ma, Hongyang Xu, Canqing Yu, Jun Lv, Pei Pei, Ling Yang, Yiping Chen, Zhengming Chen, Hongbing Shen, Feng Chen, Yang Zhao, Liming Li, On behalf of the China Kadoorie Biobank Collaborative Group · 发表于：Chinese Medical Journal · 年份：2024 · DOI：10.1097/cm9.0000000000003177 · 被引用次数：4 · 研究领域：Nutritional Studies and Diet、Consumer Attitudes and Food Labeling、Obesity, Physical Activity, Diet

BACKGROUND: Spicy food consumption has been reported to be inversely associated with mortality from multiple diseases. However, the effect of spicy food intake on the incidence of vascular diseases in the Chinese population remains unclear. This study was conducted to explore this association. METHODS: This study was performed using the large-scale China Kadoorie Biobank (CKB) prospective cohort of 486,335 participants. The primary outcomes were vascular disease, ischemic heart disease (IHD), major coronary events (MCEs), cerebrovascular disease, stroke, and non-stroke cerebrovascular disease. A Cox proportional hazards regression model was used to assess the association between spicy food consumption and incident vascular diseases. Subgroup analysis was also performed to evaluate the heterogeneity of the association between spicy food consumption and the risk of vascular disease stratified by several basic characteristics. In addition, the joint effects of spicy food consumption and the healthy lifestyle score on the risk of vascular disease were also evaluated, and sensitivity analyses were performed to assess the reliability of the association results. RESULTS: During a median follow-up time of 12.1 years, a total of 136,125 patients with vascular disease, 46,689 patients with IHD, 10,097 patients with MCEs, 80,114 patients with cerebrovascular disease, 56,726 patients with stroke, and 40,098 patients with non-stroke cerebrovascular disease were identified. Participants wh...