Polysaccharides derived from Deglet Noor dates modulate amoxicillin-induced dysbiosis and enhance intestinal barrier function

作者：Hidayat Ullah, Muhsin Ali, Renzhen Ma, Yamina Alioui, Sharafat Ali, Muhammad Ilyas, Mujeeb Ur Rahman, Nabeel Ahmed Farooqui, Nimra Zafar Siddiqui, Yi Xin, Liang Wang · 发表于：Journal of Functional Foods · 年份：2024 · DOI：10.1016/j.jff.2024.106350 · 被引用次数：5 · 研究领域：Date Palm Research Studies、African Botany and Ecology Studies、Polysaccharides Composition and Applications

• Deglet Noor Polysaccharides: Investigates their potential in mitigating antibiotic-induced gut dysbiosis. • Restorative Effects: Reverses dysbiosis by enriching beneficial bacteria and suppressing pathogens. • Enhanced Mucin Production: Improves gut barrier integrity. • Anti-inflammatory Response: Suppresses cytokines, suggesting therapeutic potential for gut disorders. Despite their well-known nutritional importance, the consumption of dates is linked to several health benefits. This study investigates the potential of Deglet Noor polysaccharides (DP) in reverting gut dysbiosis. The study aimed to characterize and explore the prebiotic properties of Deglet Noor date polysaccharides (DP) in alleviating antibiotic-induced diarrhea by enhancing intestinal integrity, increasing mucin production, and modulating gut microbiota. Male BALB/C 5–6-week-old mice were utilized, with amoxicillin administered for 14 days followed by treatment with DP for the subsequent 14 days. The alteration of intestinal flora due to antibiotics and the restorative effects of DP were explored using the “Illumina MiSeq platform”. Amoxicillin administration for 14 days resulted in a significant reduction in the diversity and abundance of bacteria, altering the intestinal flora at various taxonomic levels. Antibiotic treatment led to an increase in pathogenic strains (Proteobacteria, Enterococcus, and Bacteroides ), while supplementation with DP reversed the antibiotic-induced dysbiosis and increased the...