Effects of in utero exposure to Δ-9-tetrahydrocannabinol on cardiac extracellular matrix expression and vascular transcriptome in rhesus macaques

作者：Hillary H. Le, Lyndsey E. Shorey‐Kendrick, Monica T. Hinds, Owen J. T. McCarty, Jamie O. Lo, Deirdre E.J. Anderson · 发表于：American Journal of Physiology-Heart and Circulatory Physiology · 年份：2024 · DOI：10.1152/ajpheart.00181.2024 · 被引用次数：9 · 研究领域：Cannabis and Cannabinoid Research、Birth, Development, and Health、Neuroscience of respiration and sleep

Prenatal cannabis use is increasing and despite the public health relevance, there is limited safety data regarding its impact on offspring cardiovascular health outcomes. We used a translational, nonhuman primate model of daily edible Δ-9-tetrahydrocannabinol (THC) consumption during pregnancy to assess its effects on the fetal cardiovascular system. THC-exposed fetal vascular tissues displayed upregulation of genes involved in cellular metabolism and inflammation, suggesting that prenatal THC exposure may impact fetal vascular tissues.