Impact of Heating Conventional Cigarettes With a Novel Device on Health-Related Biomarkers and Cigarette Use Patterns Among Chinese Adult Smokers Unwilling to Quit: A Pilot Randomized Controlled Trial

作者：Shuilian Chu, Xiaobo Li, Di Zhang, Hang Jing, Feng Lin, Yingting Zuo, Jiachen Li, Haomiao Ma, Zhaohui Tong, Lirong Liang · 发表于：Nicotine & Tobacco Research · 年份：2024 · DOI：10.1093/ntr/ntae177 · 被引用次数：9 · 研究领域：Smoking Behavior and Cessation、Fibromyalgia and Chronic Fatigue Syndrome Research、Indoor Air Quality and Microbial Exposure

INTRODUCTION: We evaluated the impact of heating conventional cigarettes with a novel heated tobacco product (HTP) device on biomarkers and cigarette use patterns in Chinese adult smokers unwilling to quit smoking. AIMS AND METHODS: In this pilot randomized controlled trial, 50 eligible participants were allocated to either control group (smoking conventional cigarettes) or HTP device group (switching to using heated conventional cigarettes by the HTP device). Participants in the HTP device group went through a 2-day run-in period and then used heated conventional cigarettes exclusively for 5 days, followed by flexible use for 14 days. Five biomarkers of exposure (BoEs) were measured at baseline and on day 7. Thirteen biomarkers of biological effect (BoBEs) were measured at baseline and on day 21. Safety, daily cigarette consumption, craving, withdrawal symptoms, and device acceptability, were assessed. RESULTS: BoE levels decreased by 26.4 % to 71.4% from baseline in the HTP device group, while BoBE levels did not significantly change in either group. In the HTP group, 56% exclusively used heated conventional cigarettes during the flexible use period, experiencing reduced cravings and withdrawal symptoms, while dual users consumed more cigarettes. Mild to moderate device-related reactions were reported in 36% of users. Satisfaction, taste, and harm reduction belief scores averaged 7.4, 6.6, and 8.7 (out of 10), respectively. CONCLUSIONS: Switching to heated conventional ciga...