Influencing factors of different metabolic status in hospitalized patients with schizophrenia

作者：Mubing Ding, Shaotong Zhang, Zaochen Zhu, Renliang Cai, Jin Fang, Chao Zhou, Xiangrong Zhang, Xinyu Fang · 发表于：Frontiers in Psychiatry · 年份：2024 · DOI：10.3389/fpsyt.2024.1436142 · 被引用次数：3 · 研究领域：Schizophrenia research and treatment、Tryptophan and brain disorders、Cognitive Functions and Memory

Objective: The aim of this study was to explore the risk factors for different metabolic status in patients with schizophrenia. Methods: A total of 968 hospitalized patients with schizophrenia were recruited. Fasting blood glucose (GLU) and lipid profile, including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were measured. Schizophrenia patients were divided into four groups: normal metabolism and weight (NMNW), abnormal metabolism and normal weight (AMNW), normal metabolism and overweight/obesity (NMO), and abnormal metabolism and overweight/obesity (AMO). Results: Our results showed that NMNW, AMNW, NMO, and AMO accounted for 25.3%, 12.7%, 25.4%, and 36.6%, respectively. There were significant differences in age, disease duration, body mass index (BMI), waist circumference, chronic disease, systolic blood pressure (SBP), diastolic blood pressure (DBP), GLU, TG, TC, HDL-C, and LDL-C among these four groups (all p < 0.05). With the NMNW group as the reference, the disordered multiple classification regression analysis showed that chronic disease was a significant risk factor for AMNW (OR = 5.271, 95% CI = 3.165 to 8.780, p < 0.001) and AMO (OR = 3.245, 95% CI = 2.004 to 5.254, p < 0.001), age was an important protective factor for NMO (OR = 0.968, 95% CI = 0.943 to 0.994, p = 0.015) and AMO (OR = 0.973, 95% CI = 0.948 to 0.999, p < 0.042), waist circumference was a significant risk fa...