Role of miRNA‑122 in cancer (Review)

作者：Jing Zhang, Linghua Wu, Rong Ding, Xin Deng, Zeshan Chen · 发表于：International Journal of Oncology · 年份：2024 · DOI：10.3892/ijo.2024.5671 · 被引用次数：12 · 研究领域：MicroRNA in disease regulation、Circular RNAs in diseases

MicroRNAs (miRNAs) are small non-coding RNAs that serve key roles in cell proliferation, migration, invasion and apoptosis by regulating gene expression.In malignant tumors, miRNA-122 serves either as a tumor suppressor or oncogene, influencing tumor progression via downstream gene targeting.However, the precise role of miRNA-122 in cancer remains unclear.miRNA-122 is a potential biomarker and modulator of radiotherapy and chemotherapy.The present review aimed to summarize the roles of miRNA-122 in cancer, its potential as a biomarker for diagnosis and prognosis and its implications in cancer therapy, including radiotherapy and chemotherapy, alongside strategies for systemic delivery. Contents1. Introduction 2. miRNA-122 and cancer 3. miRNA-122 as a biomarker 4. Application of miRNA-122 in chemotherapy and radiotherapy 5. Systemic delivery strategies for miRNA-122 6. Clinical implications and limitations 7. Conclusion