Aberrant functional connectivity in anterior cingulate gyrus subregions in migraine without aura patients

作者：Jinming Cheng, Yan Li, Keyang Chen, Yungang Cao, Kun Liu, Xi Zhang, Wu Xiaoyuan, Zhihong Wang, Xiaozheng Liu, Litao Li · 发表于：Frontiers in Neurology · 年份：2024 · DOI：10.3389/fneur.2024.1412117 · 被引用次数：4 · 研究领域：Migraine and Headache Studies、Functional Brain Connectivity Studies、Transcranial Magnetic Stimulation Studies

Background: The anterior cingulate gyrus (ACG) is an important regulatory region for pain-related information. However, the ACG is composed of subregions with different functions. The mechanisms underlying the brain networks of different subregions of the ACG in patients with migraine without aura (MwoA) are currently unclear. Methods: In the current study, resting-state functional magnetic resonance imaging (rsfMRI) and functional connectivity (FC) were used to investigate the functional characteristics of ACG subregions in MwoA patients. The study included 17 healthy volunteers and 28 MwoA patients. The FC calculation was based on rsfMRI data from a 3 T MRI scanner. The brain networks of the ACG subregions were compared using a general linear model to see if there were any differences between the two groups. Spearman correlation analysis was used to examine the correlation between FC values in abnormal brain regions and clinical variables. Results: Compared with healthy subjects, MwoA patients showed decreased FC between left subgenual ACG and left middle cingulate gyrus and right middle temporal gyrus. Meanwhile, MwoA patients also showed increased FC between pregenual ACG and right angular gyrus and increased FC between right pregenual ACG and right superior occipital gyrus. The FC values between pregenual ACG and right superior occipital gyrus were significantly positively correlated with the visual analogue scale. Conclusion: Disturbances of FC between ACG subregions an...