Treatment of Iron‐Induced Cutaneous Hyperpigmentation With Energy‐Based Devices

作者：Ajay Sharma, Nicole M. Golbari, Solomiya Grushchak, Adriana Ribas Andrade, Christopher B. Zachary · 发表于：Lasers in Surgery and Medicine · 年份：2024 · DOI：10.1002/lsm.23825 · 被引用次数：6 · 研究领域：Dermatologic Treatments and Research、Laser Applications in Dentistry and Medicine、Burn Injury Management and Outcomes

ABSTRACT Objectives Iatrogenic cutaneous siderosis is a well‐recognized dermatologic complication after parenteral iron infusion. The condition manifests as discrete, hyperpigmented patches near the site of injection. Most cases do not resolve spontaneously, leading to significant aesthetic and psychological distress to patients. A recent case of iatrogenic cutaneous siderosis at our institution prompted a systematic review of the efficacy of energy‐based devices previously reported in the treatment of this condition. Methods PubMed and Cochrane databases were searched for all peer‐reviewed articles published using the following search terms: “iron OR heme OR hemosiderosis OR siderosis” and “hyperpigmentation OR staining OR tattoo.” Articles reporting on energy‐based devices in the treatment of iron‐induced hyperpigmentation were included. Results A total of seven articles and 54 total patients were included in this review. All patients, including the patient treated at our institution, were female, with an average age of 44 years. Hyperpigmentation was most commonly associated with intravenous iron infusion (48/54, 89%), on the arm or forearm (44/54, 81%), and used for the treatment of underlying iron deficiency anemia (54/54, 100%). The application of six different nanosecond or picosecond quality‐switched laser systems was reported in the treatment of cutaneous siderosis, with wavelengths ranging from 532 to 1064 nm. Spot sizes varied between 2 and 7 mm, with energy fluenc...