Association of cigarette smoking, smoking cessation with the risk of cardiometabolic multimorbidity in the UK Biobank

作者：Shuo Zhang, Zhou Jiang, Hao Zhang, Yuxin Liu, Jike Qi, Yan Yu, Ting Wang, Ping Zeng · 发表于：BMC Public Health · 年份：2024 · DOI：10.1186/s12889-024-19457-y · 被引用次数：14 · 研究领域：Chronic Disease Management Strategies、Cardiovascular Health and Risk Factors、Genetic Associations and Epidemiology

Abstract Background To investigate the association between cigarette smoking, smoking cessation and the trajectory of cardiometabolic multimorbidity (CMM), and further to examine the association of age at smoking initiation and smoking cessation with CMM. Methods This study included 298,984 UK Biobank participants without cardiometabolic diseases (CMDs) (including type 2 diabetes, coronary heart diseases, stroke, and hypertension) at baseline. Smoking status was categorized into former, current, and never smokers, with age at smoking initiation and smoking cessation as a proxy for current and former smokers. The multi-state model was performed to evaluate the association between cigarette smoking, smoking cessation and CMM. Results During a median follow-up of 13.2 years, 59,193 participants developed first cardiometabolic disease (FCMD), 14,090 further developed CMM, and 16,487 died. Compared to former smokers, current smokers had higher risk at all transitions, with hazard ratio (95% confidence interval) = 1.59 (1.55 ∼ 1.63) vs. 1.18 (1.16 ∼ 1.21) ( P = 1.48 × 10 − 118 ) from health to FCMD, 1.40 (1.33 ∼ 1.47) vs. 1.09 (1.05 ∼ 1.14) ( P = 1.50 × 10 − 18 ) from FCMD to CMM, and 2.87 (2.72 ∼ 3.03) vs. 1.38 (1.32 ∼ 1.45) ( P < 0.001) from health, 2.16 (1.98 ∼ 2.35) vs. 1.25 (1.16 ∼ 1.34) ( P = 1.18 × 10 − 46 ) from FCMD, 2.02 (1.79 ∼ 2.28) vs. 1.22 (1.09 ∼ 1.35) ( P = 3.93 × 10 − 17 ) from CMM to death; whereas quitting smoking reduced the risk attributed to cigarette smoki...