Cortical structure and subcortical volumes in conduct disorder: a coordinated analysis of 15 international cohorts from the ENIGMA-Antisocial Behavior Working Group

作者：Yidian Gao, Marlene Staginnus, Yidian Gao, Marlene Staginnus, Sophie Townend, Celso Arango, Sahil Bajaj, Tobias Banaschewski, Edward D. Barker, Vivek Benegal, Kathryn Berluti, Anka Bernhard, Robert J.R. Blair, Charlotte P.S. Boateng, Arun L.W. Bokde, Daniel Brandeis, Jan K. Buitelaar, S. Alexandra Burt, Elise M. Cardinale, Josefina Castro‐Fornieles, Hui Chen, Xianliang Chen, S. C. Chester, Olivier F. Colins, Harriet Cornwell, Michael Craig, Ana I. Cubillo, Sylvane Desrivières, Dana E. Díaz, Andrea Dietrich, Daifeng Dong, Anouk H. Dykstra, Barbara Franke, Christine M. Freitag, Jeffrey Glennon, Karen González-Madruga, Cindy C. Hagan, Pieter J. Hoekstra, Bharath Holla, Luke W. Hyde, Karim Ibrahim, Nimrah Jabeen, Rebecca L. Jackson, Yali Jiang, Gregor Kohls, Kerstin Konrad, Alexandra Kypta-Vivanco, Kim Lamers, Ren Ma, Abigail A. Marsh, Anne Martinelli, Jean‐Luc Martinot, Kalina J. Michalska, Qingsen Ming, Silvia Minosse, Colter Mitchell, Christopher S. Monk, Declan Murphy, Leah E. Mycue, Jilly Naaijen, Maaike Oosterling, Luca Passamonti, Ruth Pauli, Maria Jose Penzol Alonso, Harriet Phillips, Montana L. Ploe, Nora Maria Raschle, Ruth Roberts, Jack Rogers, Mireia Rosa-Justícia, Ilyas Sagar-Ouriaghli, Ulrike Schulze, Günter Schumann, Arjun Sethi, Areti Smaragdi, Edmund Sonuga‐Barke, Christina Stadler, Michael C. Stevens, Denis G. Sukhodolsky, Kate Sully, Xiaoqiang Sun, Nicola Toschi, Christopher Townsend, Nic J. A. van der Wee, Robert Vermeiren, Essi Viding, Xiaoping Wang, Heidi B. Westerman, Qiong Wu, Shuqiao Yao, Jibiao Zhang, Jiansong Zhou, Jiawei Zhou, Neda Jahanshad, Sophia I. Thomopoulos, Christopher R. K. Ching, Melody J.Y. Kang, Paul M. Thompson, Eduard T. Klapwijk, Daniel S. Pine, Arielle Baskin–Sommers, Charlotte A. M. Cecil, Moji Aghajani, Esther Walton, Graeme Fairchild, Stéphane A. De Brito · 发表于：The Lancet Psychiatry · 年份：2024 · DOI：10.1016/s2215-0366(24)00187-1 · 被引用次数：31 · 研究领域：Psychopathy, Forensic Psychiatry, Sexual Offending、Schizophrenia research and treatment、Neural and Behavioral Psychology Studies

BACKGROUND: Conduct disorder is associated with the highest burden of any mental disorder in childhood, yet its neurobiology remains unclear. Inconsistent findings limit our understanding of the role of brain structure alterations in conduct disorder. This study aims to identify the most robust and replicable brain structural correlates of conduct disorder. METHODS: The ENIGMA-Antisocial Behavior Working Group performed a coordinated analysis of structural MRI data from 15 international cohorts. Eligibility criteria were a mean sample age of 18 years or less, with data available on sex, age, and diagnosis of conduct disorder, and at least ten participants with conduct disorder and ten typically developing participants. 3D T1-weighted MRI brain scans of all participants were pre-processed using ENIGMA-standardised protocols. We assessed group differences in cortical thickness, surface area, and subcortical volumes using general linear models, adjusting for age, sex, and total intracranial volume. Group-by-sex and group-by-age interactions, and DSM-subtype comparisons (childhood-onset vs adolescent-onset, and low vs high levels of callous-unemotional traits) were investigated. People with lived experience of conduct disorder were not involved in this study. FINDINGS: We collated individual participant data from 1185 young people with conduct disorder (339 [28·6%] female and 846 [71·4%] male) and 1253 typically developing young people (446 [35·6%] female and 807 [64·4%] male), w...