Concomitant sickle cell disease and systemic lupus erythematosus: A single‐center case series

作者：Ajibike Lapite, Luisana M. Sánchez, Ana Luiza Altaffer, Meredith Rae, Andrea A. Ramirez, Eyal Muscal, Cagri Yildirim‐Toruner, Venée N. Tubman · 发表于：Pediatric Blood & Cancer · 年份：2024 · DOI：10.1002/pbc.31194 · 被引用次数：3 · 研究领域：Blood groups and transfusion、Hemoglobinopathies and Related Disorders、Systemic Lupus Erythematosus Research

Sickle cell disease (SCD) and systemic lupus erythematosus (SLE) are two uncommon disorders each characterized by multisystemic manifestations. Individuals with SCD exhibit abnormalities in the complement pathway, which may predispose patients to develop autoimmune disorders such as SLE. As many manifestations of SLE mimic those of SCD, diagnosis and therapeutic management of SLE in a patient with known SCD may be delayed. In this study, we describe our institutional experience of diagnosing and managing concomitant SCD and SLE. We offer insights into the complex interplay between these conditions to enhance early recognition and effective management of concurrent SCD and SLE.