Serum albumin, genetic susceptibility, and risk of venous thromboembolism

作者：Yuyang Sun, Jun Deng, Yajie Ding, Shanshan Luo, Si Li, Yunlong Guan, Xi Cao, Xingjie Hao, Yu Hu · 发表于：Research and Practice in Thrombosis and Haemostasis · 年份：2024 · DOI：10.1016/j.rpth.2024.102509 · 被引用次数：9 · 研究领域：Blood Coagulation and Thrombosis Mechanisms、Blood properties and coagulation、Venous Thromboembolism Diagnosis and Management

Background: Previous research on the association between serum albumin (ALB) and venous thromboembolism (VTE) has produced inconclusive results. The polygenic risk score is constructed from a set of independent risk variants associated with a disorder, enabling the identification of a larger fraction of the population at comparable or greater disease risk. It is still unknown whether ALB and genetic factors jointly contribute to the incidence of VTE. Objectives: The present study aimed to explore ALB, genetic susceptibility, and the risk of VTE. Methods: The present investigation was an analysis of prospectively collected data from UK Biobank, a population-based, longitudinal cohort. Cox proportional models were used to calculate hazard ratios and 95% CIs for VTE. The Kaplan-Meier curve was utilized to visualize the cumulative risk of VTE according to different serum ALB levels, and the restricted cubic spline model was leveraged to explore the exposure-response relationship among ALB levels and VTE risk. Results: During median follow-up of 13.5 years, 11,502 cases with VTE were diagnosed among 417,113 participants in the UK Biobank. The lower ALB levels were associated with a higher risk for VTE. Individuals with both a high genetic risk and lowest ALB level had the highest risk of VTE (hazard ratio, 3.89; 95% CI, 3.41-4.43), compared with those with low genetic risk and highest ALB level. The positive joint effects of low ALB and polygenic risk score increased the risk of V...